FOXN2

Across TCGA patient cohorts, FOXN2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXN2-associated genes across cancer lineages are p70-S6K_pT389, Annexin-1, and Rictor_pT1135. Each is linked with FOXN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN2-to-partner and partner-to-FOXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by FOXN2-low versus FOXN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN2→partner) and Y-score (partner→FOXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.164	-2.115	.014	.016	3	2
UCEC	Annexin-1 →	+0.683	+3.926	<.001	<.001	3	2
UCEC	Rictor_pT1135 →	-0.090	-1.807	.012	.025	3	2
UCEC	Src_pY527 →	-0.310	-1.874	.041	.049	3	2
UCEC	Chk2_pT68 →	-0.166	-2.558	.011	.010	3	2
UCEC	14-3-3_beta →	-0.083	-1.847	.019	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

p70-S6K_pT389 by FOXN2 expression — UCEC

Explore this box plot interactively →