FOXN2

Across TCGA cell cohorts, FOXN2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXN2-associated genes across cancer lineages are ASB17, FOLR2, and GOT1L1. Each is linked with FOXN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN2-to-partner and partner-to-FOXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by FOXN2-low versus FOXN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN2→partner) and Y-score (partner→FOXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASB17 →	+0.011	+3.217	<.001	.006	3	1
LARGE_INTESTINE	FOLR2 →	+0.050	+3.716	.009	.003	3	1
LARGE_INTESTINE	GOT1L1 →	+0.020	+3.700	<.001	.009	3	1
LARGE_INTESTINE	MUC7 →	+0.075	+3.115	<.001	.004	3	1
LARGE_INTESTINE	ADIG →	+0.021	+3.562	<.001	.002	3	1
LARGE_INTESTINE	ZNF723 →	+0.095	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ASB17 by FOXN2 expression — LARGE_INTESTINE

Explore this box plot interactively →