FOXN1

Across TCGA patient cohorts, FOXN1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXN1-associated genes across cancer lineages are FoxM1, INPP4B, and JNK2. Each is linked with FOXN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN1-to-partner and partner-to-FOXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by FOXN1-low versus FOXN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN1→partner) and Y-score (partner→FOXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.221	+2.009	.026	.017	3	2
UCEC	INPP4B →	-0.269	-2.222	.030	.009	3	2
UCEC	JNK2 →	+0.285	+3.348	<.001	.004	3	2
UCEC	ATM →	-0.447	-1.678	.010	.023	3	2
UCEC	Cyclin-E2 →	+0.176	+1.817	.006	.015	3	2
UCEC	eIF4E →	+0.169	+2.335	.036	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

FoxM1 by FOXN1 expression — UCEC

Explore this box plot interactively →