FOXN1

Across TCGA cell cohorts, FOXN1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXN1-associated genes across cancer lineages are GUCY2F, GSG1L2, and GUCA1A. Each is linked with FOXN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXN1-to-partner and partner-to-FOXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCY2F grouped by FOXN1-low versus FOXN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXN1→partner) and Y-score (partner→FOXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GUCY2F →	+0.007	+3.103	.007	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GUCA1A →	+0.070	+4.104	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GUCY2F by FOXN1 expression — LARGE_INTESTINE

Explore this box plot interactively →