FOXM1

Across TCGA patient cohorts, FOXM1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,672 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FOXM1-associated genes across cancer lineages are SIGLEC6, SFRP4, and DNPH1. Each is linked with FOXM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXM1-to-partner and partner-to-FOXM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXM1 versus SIGLEC6 in BRCA, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXM1→partner) and Y-score (partner→FOXM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SIGLEC6 →	-0.968	-1.201	.001	.005	3	2
BRCA	SFRP4 →	-1.731	-1.171	.001	.001	3	2
BRCA	DNPH1 →	+1.140	+1.322	<.001	.002	3	2
BRCA	MAN1C1 →	-0.954	-0.890	<.001	<.001	3	2
BRCA	PKMYT1 →	+1.208	+1.490	.001	.001	3	2
LSCC	CCNB1 →	+0.967	+0.895	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,672 associations by consensus.

FOXM1 vs SIGLEC6 — BRCA

Explore this scatter interactively →