FOXL3

Across TCGA pan-cancer cohorts, FOXL3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated FOXL3 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FOXL3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FOXL3 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LAML show a favorable association.

KIRC, CESC, and ACC are the cancer types where FOXL3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.445	0.657	<.001	138	view →
CESC	OS	Tertile	II,III,IV	0.584	0.846	.003	84	view →
ACC	OS	Tertile	All	0.135	0.750	<.001	63	view →
STAD	DFS	Tertile	All	0.535	0.747	.005	54	view →
OV	OS	Tertile	All	0.693	0.857	.001	54	view →
UVM	DFS	Tertile	III,IV	0.120	0.747	.001	45	view →
KIRP	OS	Tertile	II,III,IV	0.111	0.769	<.001	36	view →
TGCT	DFS	Tertile	II,III,IV	0.618	0.950	.025	36	view →
UCEC	OS	Tertile	All	0.852	0.931	.013	36	view →
PAAD	DFS	Tertile	II,III,IV	0.414	0.208	.009	29	view →
LUAD	DFS	Quartile	IV	0.276	0.564	.023	24	view →
PCPG	DFS	Tertile	All	0.107	0.888	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

FOXL3–KIRC (OS)

Open the KIRC breakdown →