FOXL3

Across TCGA pan-cancer cohorts, FOXL3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FOXL3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FOXL3 RNA is repressed in tumor relative to normal tissue. In most cancer types FOXL3 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and READ are the cancer types where FOXL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.580	<.001	10	view →
LUSC	Female	All	−0.160	<.001	6	view →
READ	All	II,III,IV	−0.490	.004	5	view →
KICH	All	III,IV	−0.120	.023	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FOXL3–COAD

Open the COAD breakdown →