FOXL1

Across TCGA patient cohorts, FOXL1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXL1-associated genes across cancer lineages are mTOR_pS2448, PCNA, and PDCD4. Each is linked with FOXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXL1-to-partner and partner-to-FOXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by FOXL1-low versus FOXL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXL1→partner) and Y-score (partner→FOXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.122	-1.861	.032	.049	3	2
COAD	PCNA →	+0.253	+3.012	.014	.018	3	2
UCEC	PDCD4 →	-0.556	-2.690	.002	.006	3	2
UCEC	ATM →	-0.574	-2.087	<.001	.005	3	2
UCEC	4E-BP1 →	+0.457	+2.906	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.610	+3.584	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

mTOR_pS2448 by FOXL1 expression — UCEC

Explore this box plot interactively →