FOXK1

Across TCGA pan-cancer cohorts, FOXK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FOXK1 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FOXK1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FOXK1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, GBM, and LUAD are the cancer types where FOXK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.791	0.925	.008	15	view →
GBM	OS	Quartile	All	0.655	0.227	.012	11	view →
LUAD	DFS	Median	All	0.660	0.955	.011	9	view →
CCRCC	OS	Median	II,III,IV	0.749	0.928	.022	5	view →
UCEC	OS	Quartile	III,IV	0.288	1.000	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FOXK1–HNSC (OS)

Open the HNSC breakdown →