FOXK1

Across TCGA pan-cancer cohorts, FOXK1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FOXK1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FOXK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXK1 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where FOXK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.123	<.001	12	view →
HNSC	Male	All	+1.305	<.001	11	view →
LIHC	Female	II,III,IV	+1.505	<.001	9	view →
KICH	All	II,III,IV	+1.029	<.001	9	view →
LUSC	Male	II,III,IV	+1.141	<.001	7	view →
KIRC	Female	All	+0.413	<.001	7	view →
STAD	All	II,III,IV	+0.991	.001	6	view →
BRCA	All	III,IV	−0.587	<.001	6	view →
KIRP	Female	All	+0.741	.005	5	view →
UCEC	All	All	−1.303	<.001	4	view →
READ	All	All	+0.786	.004	4	view →
CHOL	All	All	+2.665	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FOXK1–COAD

Open the COAD breakdown →