FOXK1

Across TCGA patient cohorts, FOXK1 mutation is significantly associated with the RNA expression of many other genes, with 2,388 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXK1-associated genes across cancer lineages are MPPE1, PHF23, and UROD. Each is linked with FOXK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXK1-to-partner and partner-to-FOXK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPPE1 grouped by FOXK1-low versus FOXK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXK1→partner) and Y-score (partner→FOXK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MPPE1 →	+0.414	+1.981	.001	<.001	3	3
UCEC	PHF23 →	+0.310	+2.243	.009	.005	3	3
COAD	UROD →	+0.399	+2.625	.004	.005	3	3
UCEC	GALNT6 →	-0.696	-1.938	.001	.001	3	3
CESC	MBD3L3 →	+0.277	+4.144	<.001	.009	3	2
CESC	RNU1-62P →	+0.213	+4.539	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,388 associations by consensus.

MPPE1 by FOXK1 expression — UCEC

Explore this box plot interactively →