FOXK1

Across TCGA patient cohorts, FOXK1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXK1-associated genes across cancer lineages are ATM, MSH2, and PKC-b-II_pS660. Each is linked with FOXK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXK1-to-partner and partner-to-FOXK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FOXK1-low versus FOXK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXK1→partner) and Y-score (partner→FOXK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.503	-3.000	.002	.034	3	3
COAD	MSH2 →	-0.247	-2.974	.011	.035	3	2
COAD	PKC-b-II_pS660 →	-0.402	-3.169	.009	.018	3	2
COAD	Smad4 →	+0.171	+3.169	.002	.018	3	2
UCEC	Ku80 →	+0.288	+2.713	<.001	.003	3	2
UCEC	Akt_pT308 →	+0.488	+1.874	.031	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ATM by FOXK1 expression — COAD

Explore this box plot interactively →