FOXK1

Across TCGA cell cohorts, FOXK1 mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXK1-associated genes across cancer lineages are NPVF, C3orf85, and RNF8. Each is linked with FOXK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FOXK1-to-partner and partner-to-FOXK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by FOXK1-low versus FOXK1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXK1→partner) and Y-score (partner→FOXK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	4
SKIN	C3orf85 →	+0.476	+3.556	.001	.007	3	2
LARGE_INTESTINE	RNF8 →	+0.523	+3.169	.002	.009	3	2
LARGE_INTESTINE	AMD1 →	+0.562	+3.234	<.001	.004	3	2
LARGE_INTESTINE	MRPL16 →	+0.578	+2.451	.003	.009	3	2
LARGE_INTESTINE	GDPGP1 →	+0.756	+3.169	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

NPVF by FOXK1 expression — KIDNEY

Explore this box plot interactively →