Across TCGA pan-cancer cohorts, FOXJ3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FOXJ3 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FOXJ3 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FOXJ3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUSC, and ACC are the cancer types where FOXJ3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.976	0.888	.011	32	view →
LUSC	OS	Median	II,III,IV	0.259	0.742	.021	12	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
LIHC	OS	Median	All	0.167	0.688	.035	6	view →
SARC	OS	Median	All	0.238	0.826	.001	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: FOXJ3 tumor-vs-normal RNA expression · all FOXJ3 data types