Across TCGA pan-cancer cohorts, FOXJ3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FOXJ3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FOXJ3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXJ3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
KIRC, HNSC, and THCA are the cancer types where FOXJ3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOXJ3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.