Across TCGA cell cohorts, FOXI2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOXI2-associated genes across cancer lineages are SSX7, CLPSL1, and OR52N5. Each is linked with FOXI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXI2-to-partner and partner-to-FOXI2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXI2→partner) and Y-score (partner→FOXI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1
LARGE_INTESTINE	CLPSL1 →	+0.158	+4.054	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR52N5 →	+0.171	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR56B1 →	+0.048	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.486	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	KRTAP22-2 →	+0.256	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

FOXI2 survival (RNA) · tumor vs normal (RNA) · all FOXI2 data types