Across TCGA pan-cancer cohorts, FOXG1-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FOXG1-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where FOXG1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOXG1-AS1 is over-expressed in tumor, although a few such as ESCA and KICH show the opposite, repressed pattern.
COAD, ESCA, and KICH are the cancer types where FOXG1-AS1 tumor–normal differential expression is most reproducible.