Across TCGA cell cohorts, FOXE3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXE3-associated genes across cancer lineages are TTLL8, COX6A2, and OR2K2. Each is linked with FOXE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXE3-to-partner and partner-to-FOXE3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXE3→partner) and Y-score (partner→FOXE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	COX6A2 →	+0.102	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR2K2 →	+0.026	+4.095	.003	.009	3	1
LARGE_INTESTINE	ELOA3DP →	+0.039	+4.273	<.001	.006	3	1
LARGE_INTESTINE	OR10C1 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR8S1 →	+0.031	+4.095	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

FOXE3 survival (RNA) · tumor vs normal (RNA) · all FOXE3 data types