FOXD4L6

Across TCGA patient cohorts, FOXD4L6 mutation is significantly associated with the RNA expression of many other genes, with 744 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXD4L6-associated genes across cancer lineages are RNU6-709P, RNA5SP52, and RNA5SP68. Each is linked with FOXD4L6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD4L6-to-partner and partner-to-FOXD4L6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by FOXD4L6-low versus FOXD4L6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD4L6→partner) and Y-score (partner→FOXD4L6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-709P →	+0.450	+8.174	<.001	<.001	3	2
UCEC	RNA5SP52 →	+0.849	+2.751	<.001	.002	3	2
UCEC	RNA5SP68 →	+0.741	+3.041	<.001	<.001	3	2
UCEC	RNA5SP509 →	+0.139	+4.151	<.001	.006	3	2
UCEC	RNA5SP167 →	+0.527	+4.923	<.001	<.001	3	2
UCEC	RNA5SP377 →	+0.615	+3.461	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 744 associations by consensus.

RNU6-709P by FOXD4L6 expression — CESC

Explore this box plot interactively →