FOXD1

Across TCGA patient cohorts, FOXD1 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXD1-associated genes across cancer lineages are PRAS40_pT246 and AMPK_pT172. Each is linked with FOXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD1-to-partner and partner-to-FOXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by FOXD1-low versus FOXD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD1→partner) and Y-score (partner→FOXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.210	+2.820	.046	.036	1	1
UCEC	AMPK_pT172 →	+0.499	+2.820	.047	.036	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PRAS40_pT246 by FOXD1 expression — UCEC

Explore this box plot interactively →