FOXD1

Across TCGA cell cohorts, FOXD1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FOXD1-associated genes across cancer lineages are CT47B1, DEFA3, and FOXR2. Each is linked with FOXD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD1-to-partner and partner-to-FOXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT47B1 grouped by FOXD1-low versus FOXD1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD1→partner) and Y-score (partner→FOXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CT47B1 →	+0.023	+5.000	<.001	.006	3	1
PANCREAS	DEFA3 →	+0.070	+5.000	<.001	.006	3	1
SOFT_TISSUE	FOXR2 →	+1.309	+3.635	<.001	.007	3	1
SOFT_TISSUE	AKR1C4 →	+0.555	+3.736	<.001	.008	3	1
SOFT_TISSUE	TRIM40 →	+0.008	+3.882	.009	.004	3	1
BLOOD_Lymphoma	PROKR2 →	+0.057	+4.350	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CT47B1 by FOXD1 expression — PANCREAS

Explore this box plot interactively →