FOXC1

Across TCGA cell cohorts, FOXC1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXC1-associated genes across cancer lineages are ADIPOQ, AVP, and IFNA16. Each is linked with FOXC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXC1-to-partner and partner-to-FOXC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIPOQ grouped by FOXC1-low versus FOXC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC1→partner) and Y-score (partner→FOXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADIPOQ →	+0.019	+4.813	<.001	<.001	3	2
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	IFNA16 →	+0.018	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	EDDM3A →	+0.081	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	SPINK14 →	+0.213	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	GAGE12G →	+0.024	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ADIPOQ by FOXC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →