Across TCGA pan-cancer cohorts, FOXB2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FOXB2 data layer compared with 14 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FOXB2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FOXB2 expression acts as an unfavorable survival marker.

HNSC and LUSC are the cancer types where FOXB2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.079	0.756	<.001	18	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: FOXB2 tumor-vs-normal RNA expression · all FOXB2 data types