Across TCGA cell cohorts, FOXB2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXB2-associated genes across cancer lineages are SLC35G3, SMR3A, and CYP11B1. Each is linked with FOXB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXB2-to-partner and partner-to-FOXB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXB2→partner) and Y-score (partner→FOXB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC35G3 →	+0.017	+4.415	<.001	.007	3	2
STOMACH	SMR3A →	+0.030	+4.285	<.001	.007	3	1
STOMACH	CYP11B1 →	+0.012	+4.285	<.001	.007	3	1
STOMACH	OR6X1 →	+0.017	+4.285	<.001	.007	3	1
SKIN	RBMY1J →	+0.007	+5.562	<.001	<.001	3	1
LARGE_INTESTINE	G6PC2 →	+0.025	+3.099	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

FOXB2 survival (RNA) · tumor vs normal (RNA) · all FOXB2 data types