FOXA3

Across TCGA cell cohorts, FOXA3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOXA3-associated genes across cancer lineages are OR1A1, OR1L1, and PRAMEF18. Each is linked with FOXA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXA3-to-partner and partner-to-FOXA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1A1 grouped by FOXA3-low versus FOXA3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA3→partner) and Y-score (partner→FOXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR1A1 →	+0.023	+5.169	<.001	.005	3	1
BREAST	OR1L1 →	+0.036	+5.169	<.001	.005	3	1
BREAST	PRAMEF18 →	+0.006	+5.169	<.001	.005	3	1
BLOOD_Leukemia	APCS →	+0.070	+4.201	<.001	.001	3	1
BLOOD_Leukemia	DPT →	+1.256	+4.091	<.001	.002	3	1
BLOOD_Leukemia	CPXCR1 →	+0.061	+3.971	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR1A1 by FOXA3 expression — BREAST

Explore this box plot interactively →