FOXA2

Across TCGA patient cohorts, FOXA2 mutation is significantly associated with the RNA expression of many other genes, with 622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXA2-associated genes across cancer lineages are MIR4743, PGAM1P1, and MIR3909. Each is linked with FOXA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXA2-to-partner and partner-to-FOXA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4743 grouped by FOXA2-low versus FOXA2-high in UCS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA2→partner) and Y-score (partner→FOXA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	MIR4743 →	+0.486	+5.700	<.001	.002	3	3
UCS	PGAM1P1 →	+0.110	+5.087	<.001	.006	3	2
UCS	MIR3909 →	+0.626	+5.700	<.001	.002	3	2
CESC	CHEK2P3 →	+0.212	+4.757	<.001	.004	3	2
CESC	FSBP →	+0.021	+3.874	<.001	.006	3	2
CESC	MIR7976 →	+0.714	+4.269	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 622 associations by consensus.

MIR4743 by FOXA2 expression — UCS

Explore this box plot interactively →