FOXA2

Across TCGA pan-cancer cohorts, FOXA2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FOXA2 data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FOXA2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FOXA2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

KIRC, HNSC, and KIRP are the cancer types where FOXA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.543	0.696	<.001	143	view →
HNSC	OS	Median	All	0.578	0.735	<.001	126	view →
KIRP	OS	Median	All	0.581	0.788	<.001	120	view →
UCEC	DFS	Tertile	All	0.816	0.505	<.001	100	view →
ACC	DFS	Median	All	0.232	0.644	<.001	83	view →
SCLC	OS	Quartile	All	0.733	0.285	.003	76	view →
THYM	DFS	Tertile	All	0.489	0.810	<.001	59	view →
OV	OS	Median	III,IV	0.879	0.789	.001	34	view →
LGG	OS	Quartile	All	0.727	0.854	<.001	32	view →
LUSC	DFS	Quartile	II,III,IV	0.270	0.462	.006	31	view →
UVM	DFS	Median	III,IV	0.316	0.805	.026	18	view →
COAD	OS	Median	III,IV	0.906	0.659	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FOXA2–KIRC (DFS)

Open the KIRC breakdown →