FOXA2

Across TCGA patient cohorts, FOXA2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXA2-associated genes across cancer lineages are Ku80, MAPK_pT202_Y204, and ARID1A. Each is linked with FOXA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXA2-to-partner and partner-to-FOXA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by FOXA2-low versus FOXA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA2→partner) and Y-score (partner→FOXA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.230	+1.598	.025	.044	3	1
UCEC	MAPK_pT202_Y204 →	-0.490	-2.321	.016	.034	3	1
UCEC	ARID1A →	+0.175	+1.592	.028	.044	3	1
UCEC	B-Raf →	+0.367	+2.807	.019	.003	3	1
UCEC	EGFR_pY1068 →	-0.223	-2.807	.042	.003	2	1
UCEC	Shc_pY317 →	-0.155	-2.321	.019	.034	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by FOXA2 expression — UCEC

Explore this box plot interactively →