FOXA2

Across TCGA cell cohorts, FOXA2 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible FOXA2-associated genes across cancer lineages are OPRPN, GPR101, and OR56A1. Each is linked with FOXA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXA2-to-partner and partner-to-FOXA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by FOXA2-low versus FOXA2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA2→partner) and Y-score (partner→FOXA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OPRPN →	+0.057	+4.887	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.106	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A1 →	+0.059	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR2M2 →	+0.202	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.077	+4.736	<.001	.009	3	2
BLOOD_Lymphoma	SPATS1 →	+0.748	+3.714	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

OPRPN by FOXA2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →