FOS

Across TCGA cell cohorts, FOS mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOS-associated genes across cancer lineages are VSX2, ACTRT1, and C20orf85. Each is linked with FOS in more than 1 cancer types. Because this analysis shows association rather than direction, both FOS-to-partner and partner-to-FOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VSX2 grouped by FOS-low versus FOS-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOS→partner) and Y-score (partner→FOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VSX2 →	+0.026	+4.258	.002	.002	3	1
BLOOD_Leukemia	ACTRT1 →	+0.014	+4.786	.004	<.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.018	+4.384	.001	.006	3	1
BLOOD_Leukemia	DPP6 →	+0.420	+4.108	<.001	.003	3	1
BLOOD_Leukemia	HCN4 →	+0.063	+3.855	<.001	.007	3	1
BLOOD_Leukemia	SLC35G3 →	+0.034	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

VSX2 by FOS expression — BLOOD_Leukemia

Explore this box plot interactively →