FOLR3

Across TCGA cell cohorts, FOLR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,766 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FOLR3-associated GO terms across cancer lineages are Regulation of extrinsic apoptotic signaling pathway via death domain receptors, Regulation of vasculature development, and Regulation of cell-substrate adhesion. Each is linked with FOLR3 in more than 8 cancer types. Because this analysis shows association rather than direction, both FOLR3-to-partner and partner-to-FOLR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of extrinsic apoptotic signaling pathway via death domain receptors grouped by FOLR3-low versus FOLR3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOLR3→partner) and Y-score (partner→FOLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.150	+1.060	<.001	.002	3	9
BONE	Regulation of vasculature development →	+0.129	+1.630	<.001	<.001	3	8
BONE	Regulation of cell-substrate adhesion →	+0.144	+1.530	<.001	.001	3	8
BONE	Protein targeting to membrane →	+0.077	+1.523	<.001	.001	3	7
OVARY	Acute inflammatory response →	+0.142	+2.071	.001	.004	3	7
BONE	Regulation of angiogenesis →	+0.123	+1.494	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,766 associations by consensus.

Regulation of extrinsic apoptotic signaling pathway via death domain receptors by FOLR3 expression — BONE

Explore this box plot interactively →