FOLR3

Across TCGA cell cohorts, FOLR3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOLR3-associated genes across cancer lineages are UMOD, BEND2, and OR10G4. Each is linked with FOLR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOLR3-to-partner and partner-to-FOLR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UMOD grouped by FOLR3-low versus FOLR3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOLR3→partner) and Y-score (partner→FOLR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UMOD →	+0.003	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	BEND2 →	+0.017	+3.959	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR10G4 →	+0.007	+4.228	.001	<.001	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.011	+4.266	<.001	.004	3	1
LARGE_INTESTINE	PPP1R2C →	+0.046	+4.095	<.001	.009	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

UMOD by FOLR3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →