FOLR2

Across TCGA pan-cancer cohorts, FOLR2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FOLR2 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FOLR2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FOLR2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where FOLR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.462	1.000	.003	32	view →
LUAD	DFS	Median	III,IV	0.533	0.946	.003	21	view →
HNSC	DFS	Tertile	All	0.881	0.991	.008	13	view →
LSCC	OS	Median	II,III,IV	0.924	0.794	.017	11	view →
UCEC	OS	Quartile	II,III,IV	0.444	1.000	.027	10	view →
PDAC	DFS	Tertile	II,III,IV	0.310	0.481	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FOLR2–CCRCC (DFS)

Open the CCRCC breakdown →