FOLR2

Across TCGA pan-cancer cohorts, FOLR2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FOLR2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FOLR2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOLR2 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where FOLR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOLR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.744	<.001	11	view →
COAD	All	III,IV	−1.710	<.001	10	view →
BLCA	Male	III,IV	−2.532	<.001	8	view →
LUSC	All	II,III,IV	−1.764	<.001	7	view →
BRCA	All	II,III,IV	−1.835	<.001	6	view →
KICH	Male	II,III,IV	−1.565	.003	6	view →
READ	All	All	−2.120	.009	2	view →
UCEC	All	All	−1.283	<.001	2	view →
STAD	Male	III,IV	−1.266	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FOLR2–KIRC

Open the KIRC breakdown →