FOLR1

Across TCGA patient cohorts, FOLR1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FOLR1-associated genes across cancer lineages are ACVRL1, CDK1_pY15, and PKC-delta_pS664. Each is linked with FOLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOLR1-to-partner and partner-to-FOLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by FOLR1-low versus FOLR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOLR1→partner) and Y-score (partner→FOLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACVRL1 →	+0.188	+2.840	.009	.033	3	1
SKCM	CDK1_pY15 →	-0.350	-2.985	.023	.034	2	1
SKCM	PKC-delta_pS664 →	+0.206	+3.321	.033	.010	1	1
SKCM	Bid →	+0.291	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ACVRL1 by FOLR1 expression — SKCM

Explore this box plot interactively →