FOLR1

Across TCGA cell cohorts, FOLR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,018 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible FOLR1-associated GO terms across cancer lineages are Cellular response to folic acid, Negative regulation of mRNA metabolic process, and Regulation of amyloid fibril formation. Each is linked with FOLR1 in more than 17 cancer types. Because this analysis shows association rather than direction, both FOLR1-to-partner and partner-to-FOLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to folic acid grouped by FOLR1-low versus FOLR1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOLR1→partner) and Y-score (partner→FOLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cellular response to folic acid →	+1.833	+4.787	<.001	<.001	3	18
LARGE_INTESTINE	Negative regulation of mRNA metabolic process →	+0.048	+1.836	<.001	<.001	3	9
OVARY	Regulation of amyloid fibril formation →	+0.144	+3.568	<.001	<.001	3	9
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.094	+2.103	.002	.001	3	9
STOMACH	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.058	-2.945	<.001	.006	3	9
OESOPHAGUS	Regulation of myoblast fusion →	+0.132	+2.495	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,018 associations by consensus.

Cellular response to folic acid by FOLR1 expression — OVARY

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