FOLR1

Across TCGA cell cohorts, FOLR1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOLR1-associated genes across cancer lineages are OR6C2, AGRP, and DEFA4. Each is linked with FOLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOLR1-to-partner and partner-to-FOLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C2 grouped by FOLR1-low versus FOLR1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOLR1→partner) and Y-score (partner→FOLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6C2 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	AGRP →	+0.143	+3.994	<.001	.002	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR6C2 by FOLR1 expression — SKIN

Explore this box plot interactively →