FOLH1B

Across TCGA pan-cancer cohorts, FOLH1B Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated FOLH1B data layer compared with 21 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher FOLH1B Mutation is associated with better overall survival. In most high-consensus cancer types, elevated FOLH1B expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

SCLC, LUSC, and COAD are the cancer types where FOLH1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	1.000	0.526	.004	20	view →
LUSC	OS	Median	III,IV	0.011	0.684	<.001	12	view →
COAD	OS	Median	III,IV	0.221	0.782	.013	9	view →
KIRC	OS	Median	All	0.169	0.657	.002	8	view →
UCEC	DFS	Median	All	0.962	0.617	.011	8	view →
SARC	DFS	Median	All	0.101	0.632	.011	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LIHC	DFS	Median	All	0.128	0.555	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

FOLH1B–SCLC (OS)

Open the SCLC breakdown →