FOLH1B

Across TCGA pan-cancer cohorts, FOLH1B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FOLH1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where FOLH1B RNA is repressed in tumor relative to normal tissue. In most cancer types FOLH1B is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and LIHC are the cancer types where FOLH1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOLH1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−2.377	<.001	11	view →
KIRC	Male	All	−1.268	<.001	9	view →
LIHC	Male	III,IV	−2.150	<.001	8	view →
KICH	All	II,III,IV	−1.554	<.001	7	view →
CHOL	Female	All	−3.380	<.001	5	view →
PRAD	All	All	+1.216	<.001	2	view →
LUSC	All	All	+0.189	.003	2	view →
THCA	All	All	+0.073	.001	2	view →
HNSC	All	IV	+0.100	.039	1	view →
LUAD	All	All	+0.050	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FOLH1B–KIRP

Open the KIRP breakdown →