Across TCGA patient cohorts, FOCAD mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOCAD-associated genes across cancer lineages are BRCA2, p38-MAPK_pT180_Y182, and ETS-1. Each is linked with FOCAD in more than 3 cancer types. Because this analysis shows association rather than direction, both FOCAD-to-partner and partner-to-FOCAD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOCAD→partner) and Y-score (partner→FOCAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BRCA2 →	-0.215	-3.299	.005	.008	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.379	-1.227	.004	.015	3	3
SKCM	ETS-1 →	+0.311	+2.321	.007	.033	3	3
COAD	EGFR_pY1068 →	-0.400	-3.161	.013	.019	3	2
SKCM	RAD51 →	+0.263	+3.203	.007	.008	3	2
UCEC	ERK2 →	+0.139	+1.514	.014	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Exploration

FOCAD survival (RNA) · tumor vs normal (RNA) · all FOCAD data types