Across TCGA cell cohorts, FOCAD mutation is significantly associated with the RNA expression of many other genes, with 354 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOCAD-associated genes across cancer lineages are PABPN1L, OR2AK2, and CST9L. Each is linked with FOCAD in more than 1 cancer types. Because this analysis shows association rather than direction, both FOCAD-to-partner and partner-to-FOCAD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOCAD→partner) and Y-score (partner→FOCAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PABPN1L →	+0.013	+5.087	<.001	.004	3	2
BREAST	OR2AK2 →	+0.286	+5.781	<.001	.001	3	2
SOFT_TISSUE	CST9L →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.059	+5.369	<.001	.004	3	1
SOFT_TISSUE	PRAMEF18 →	+0.026	+4.930	<.001	.008	3	1
URINARY_TRACT	OR6N1 →	+0.013	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 354 associations by consensus.

Exploration

FOCAD survival (RNA) · tumor vs normal (RNA) · all FOCAD data types