FNDC8

Across TCGA patient cohorts, FNDC8 protein abundance is significantly associated with the RNA expression of many other genes, with 471 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FNDC8-associated genes across cancer lineages are GZMB, VRK1, and TNFSF13B. Each is linked with FNDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FNDC8-to-partner and partner-to-FNDC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FNDC8 versus GZMB in BRCA, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC8→partner) and Y-score (partner→FNDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GZMB →	+2.214	+0.964	<.001	.001	3	1
BRCA	VRK1 →	+0.743	+0.601	.002	.007	3	1
BRCA	TNFSF13B →	+0.971	+0.781	.005	.005	3	1
BRCA	ACOD1 →	+0.246	+0.674	.004	.003	3	1
BRCA	CCDC113 →	-0.684	-0.622	.005	.006	3	1
BRCA	ANKMY2 →	-0.830	-1.100	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 471 associations by consensus.

FNDC8 vs GZMB — BRCA

Explore this scatter interactively →