FNDC8

Across TCGA pan-cancer cohorts, FNDC8 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated FNDC8 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher FNDC8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FNDC8 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

KIRP, ACC, and MESO are the cancer types where FNDC8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.511	0.866	<.001	105	view →
ACC	OS	Median	All	0.450	0.772	<.001	95	view →
MESO	OS	Quartile	All	0.213	0.531	<.001	90	view →
SKCM	OS	Quartile	II,III,IV	0.938	0.765	<.001	56	view →
HNSC	OS	Tertile	All	0.402	0.712	<.001	35	view →
PAAD	OS	Quartile	All	0.693	0.400	<.001	24	view →
THCA	OS	Median	All	0.961	1.000	.008	22	view →
SCLC	OS	Tertile	All	0.451	0.137	.011	17	view →
UCS	OS	Median	II,III,IV	0.583	0.263	.018	14	view →
LUSC	OS	Tertile	All	0.803	0.688	.005	12	view →
LIHC	DFS	Median	All	0.488	0.595	.016	12	view →
CHOL	DFS	Tertile	III,IV	0.163	0.779	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

FNDC8–KIRP (DFS)

Open the KIRP breakdown →