FNDC8

Across TCGA patient cohorts, FNDC8 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNDC8-associated genes across cancer lineages are PDCD4, eEF2, and A-Raf_pS299. Each is linked with FNDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FNDC8-to-partner and partner-to-FNDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by FNDC8-low versus FNDC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC8→partner) and Y-score (partner→FNDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.613	-2.000	.003	.032	3	2
UCEC	eEF2 →	+0.387	+2.000	.016	.032	3	1
UCEC	A-Raf_pS299 →	-0.199	-2.700	<.001	.006	3	1
UCEC	ERK2 →	+0.230	+2.321	.008	.034	3	1
UCEC	Ku80 →	+0.341	+2.469	.001	.010	3	1
UCEC	Notch1 →	+0.177	+2.000	.005	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PDCD4 by FNDC8 expression — UCEC

Explore this box plot interactively →