FNDC8

Across TCGA cell cohorts, FNDC8 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FNDC8-associated genes across cancer lineages are CSN2, KRT85, and C1orf189. Each is linked with FNDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FNDC8-to-partner and partner-to-FNDC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by FNDC8-low versus FNDC8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC8→partner) and Y-score (partner→FNDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSN2 →	+0.033	+3.684	<.001	.006	3	1
LARGE_INTESTINE	KRT85 →	+0.544	+3.823	<.001	.006	3	1
LARGE_INTESTINE	C1orf189 →	+0.182	+4.054	<.001	.004	3	1
LARGE_INTESTINE	IQCF5 →	+0.030	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.024	+5.228	.001	.005	3	1
BLOOD_Leukemia	AADACL3 →	+0.006	+4.922	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CSN2 by FNDC8 expression — LARGE_INTESTINE

Explore this box plot interactively →