FNDC5

Across TCGA patient cohorts, FNDC5 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,957 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FNDC5-associated proteins across cancer lineages are RPL5, CACNA2D1, and TMOD2. Each is linked with FNDC5 in more than 5 cancer types. Because this analysis shows association rather than direction, both FNDC5-to-partner and partner-to-FNDC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FNDC5 versus RPL5 in GBM, with a Pearson correlation of -0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC5→partner) and Y-score (partner→FNDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.255	-1.016	<.001	<.001	3	6
HNSC	CACNA2D1 →	+0.802	+0.716	<.001	<.001	3	6
UCEC	TMOD2 →	+0.478	+0.540	.003	.001	3	6
OV	ITIH2 →	+0.633	+0.804	<.001	<.001	3	5
UCEC	LUM →	+0.723	+0.578	.002	.001	3	5
HNSC	PALM →	+0.521	+0.656	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,957 associations by consensus.

FNDC5 vs RPL5 — GBM

Explore this scatter interactively →