FNDC5

Across TCGA pan-cancer cohorts, FNDC5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FNDC5 data layer compared with 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FNDC5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FNDC5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRP show a favorable association.

LUAD, COAD, and KIRC are the cancer types where FNDC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.785	0.629	<.001	73	view →
COAD	OS	Median	III,IV	0.525	0.848	<.001	59	view →
KIRC	DFS	Quartile	IV	0.243	0.574	.001	56	view →
KIRP	DFS	Quartile	II,III,IV	0.930	0.615	.002	39	view →
UCS	DFS	Median	II,III,IV	0.575	0.149	.001	36	view →
PAAD	DFS	Quartile	All	0.552	0.259	<.001	30	view →
THCA	OS	Median	All	0.982	0.997	.004	29	view →
BLCA	OS	Tertile	II,III,IV	0.352	0.553	.011	28	view →
SCLC	OS	Median	II,III,IV	1.000	0.421	.002	21	view →
BRCA	DFS	Quartile	All	0.972	0.921	.006	16	view →
ESCA	DFS	Median	IV	0.213	0.626	.026	12	view →
LUSC	OS	Tertile	All	0.899	0.647	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FNDC5–LUAD (OS)

Open the LUAD breakdown →