FNDC5

Across TCGA cell cohorts, FNDC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,516 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FNDC5-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Regulation of DNA-templated transcription initiation. Each is linked with FNDC5 in more than 15 cancer types. Because this analysis shows association rather than direction, both FNDC5-to-partner and partner-to-FNDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by FNDC5-low versus FNDC5-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC5→partner) and Y-score (partner→FNDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.143	+0.969	<.001	.001	2	16
STOMACH	Negative regulation of myoblast fusion →	+0.159	+2.046	<.001	.009	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription initiation →	+0.059	+0.813	.009	.003	3	14
STOMACH	Regulation of transcription initiation by RNA polymerase II →	+0.069	+2.151	<.001	.005	3	14
LUNG_SCLC	Nuclear-transcribed mRNA catabolic process →	+0.054	+2.114	<.001	.001	3	13
LUNG_SCLC	mRNA catabolic process →	+0.057	+2.740	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,516 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by FNDC5 expression — BREAST

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