FNDC4

Across TCGA patient cohorts, FNDC4 mutation is significantly associated with the RNA expression of many other genes, with 247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNDC4-associated genes across cancer lineages are CYCSP22, RNA5SP412, and RPSAP60. Each is linked with FNDC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both FNDC4-to-partner and partner-to-FNDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP22 grouped by FNDC4-low versus FNDC4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC4→partner) and Y-score (partner→FNDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYCSP22 →	+0.071	+4.526	.001	.007	3	3
UCEC	RNA5SP412 →	+0.823	+2.481	<.001	.006	3	2
SKCM	RPSAP60 →	+0.069	+3.953	<.001	.005	3	2
UCEC	SNRPFP1 →	+0.751	+3.470	.004	.003	3	2
UCEC	NAMPTP2 →	+0.041	+3.442	<.001	.004	3	2
UCEC	TRBV12-4 →	+0.663	+3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 247 associations by consensus.

CYCSP22 by FNDC4 expression — HNSC

Explore this box plot interactively →