FNDC3A

Across TCGA patient cohorts, FNDC3A mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNDC3A-associated genes across cancer lineages are C-Raf, PEA-15, and 14-3-3_beta. Each is linked with FNDC3A in more than 2 cancer types. Because this analysis shows association rather than direction, both FNDC3A-to-partner and partner-to-FNDC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FNDC3A-low versus FNDC3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNDC3A→partner) and Y-score (partner→FNDC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.133	+1.765	.003	.013	3	3
BLCA	PEA-15 →	+0.300	+3.017	.007	.019	3	2
UCEC	14-3-3_beta →	-0.065	-1.847	.040	.049	3	2
UCEC	Annexin-1 →	+0.454	+1.999	.006	.008	3	2
UCEC	ATM →	-0.442	-2.893	.001	.001	3	2
UCEC	Di-Ras3 →	-0.169	-2.432	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

C-Raf by FNDC3A expression — UCEC

Explore this box plot interactively →